Scrapie Resistance (PRNP)
Gene
Protective PRNP variants make classical scrapie much less likely, but not impossible. Each goat has two copies of the gene; VGL reports two positions on it (codons 146 and 222).
Gene
Protective PRNP variants make classical scrapie much less likely, but not impossible. Each goat has two copies of the gene; VGL reports two positions on it (codons 146 and 222).
Each copy shows its own effect, so both can be seen together.
DNA studies support S146, D146 and K222 as protective PRNP variants. A protective copy makes classical scrapie much less likely; it is not scrapie-proof. US rules still treat exposed goats as susceptible.
VGL reports codons 146 and 222 separately. Read a double heterozygote such as N/S, Q/K assuming the two protective variants are on different copies. If both were on one copy, only half the kids would receive a protective copy. Keep the lab's wording. Any other codon combination doesn't match known haplotypes; check the report. The "no tested variant" haplotype is N146/Q222; it can still carry variants such as M142, Q211 or H154 that this model does not represent. Only S146, D146 and K222 are treated as protective here. Record a report with no protective variant as absent (No protective PRNP variant), keeping VGL codons 146/222 as its test scope. In a US study of 6,029 goats, resistant codon 146 genotypes occurred in Boer 47.0%, Nubian 38.6%, LaMancha 35.8%, Nigerian Dwarf 0.7% and Pygmy 0.6%. K222 occurred in Toggenburg 22.0% and Oberhasli 23.1%. These sample frequencies do not predict an untested goat.
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Guides and articles for Scrapie Resistance (PRNP) goat owners.
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